Immunosuppressive effects of human semen on macrophage of mouse / 中国免疫学杂志

ABSTRACT

This paper reports the functional changes of macrophage under the effect of SF1, the first fraction of human semen separated by Sephadex G-100. Two kinds of Balb/c mouse macrophage, i. e. peri toneal macrophage (PEC-M?) and the bone marrow derived macrophage (BM-M?), were treated by SF1 in vivo (i.p. ) and in vitro. It has been proved that SF1 is a potent immunosuppressive fraction; (1) As compared with the control, the phagocytosis of SF1 treated macrophage to SRBC coated with antibody declines significantly in terms of phagocytosis rate and index (p