The immunoregulatory effect of TLSF_(JM) on the expression of T cell IL-2R and protein Tyrosine phosphorylation / 中国免疫学杂志

ABSTRACT

The immunoregulatory effect of TLSF_(JM) on the expression of T cell IL-2R and protein Tyrosine phosphorylation (PTP) was investigated by immunohistochemistry technique. The results showed that TLSF_(JM) can markedly suppress the expression of IL-2R and PTP on PHA or TPA-stimulated human PBMC and murine IL-2 dependent cell line CTLL-2. However, there was no effect of TLSF_(JM) on the production of IL-1、IL-2 and IL-6 that play an important role in the course of T Lymphocyte prolirferation and differentiation.