An Experimental Study of High Dose of Glucocorticosteroid in Treatment of Traumatic Brain Edema in Rats / 中华创伤杂志

ABSTRACT

In order to provide an experimental evidence for clinical utility, we undertook a series of experimental studies of glucocorticosteroid to treat closed head injury and gun shot brain wound, For studies of closed injury in rats, there were four groups as follows Group 1 methyl prednisone 30mg/kg (MPG); Group 2 dexamethasone 5 mg/kg (HDMG) Group 3 dexamethasone0.5mg/kg (LDMG); and Group 4 normal saline as a control group (CG) For study of gun shot wound of brain, The dogs were divided into three groups, Grup 1 (wound group, n=8); Group 2 (treated group, n=7) and group 3 (control group, n=7). After injury, the vital signs were observed, the water content of the brain and Even' s blue level were measured and the brain were examined under optical and electronic microscopy, All results proved that secondary traumatic edema in the animals used high dose glucocotricosteroid were much more slight