INVESTIGATION OF HYPOTHALAMIC-POSTERIOR PITUITARY FUNCTION OF GROWTH RETARDED CHILDREN / 中华内分泌代谢杂志

ABSTRACT

Responses to water deprivation test of 27 children with growth retardation were obseived in an attempt to investigate their hypothalamic-posterior pituitary function, and as control, 13 cases of diabetes insipidus and 10 normal children were tested in the meantime. The results showed 1) All GH deficient children presenting with polyuria and polydipsia had severe ADH deficiency; 2) In 11 GH deficient children without polyuria and polydipsia, 7 were found endogenous ADH insufficient; 3) The children with short stature, polyuria and polydipsia but a normal GH secretion were partial ADH deficient; 4) Hypothalamic-posterior pituitary function of the children with short stature but normal GH secretion and without polyuria and polydipsia %vas normal.We conclude that growth retarded children were proved more or less insufficient of ADH, thus the posterior pituitary function of growth retarded children should be investigated as well, that water deprivation test is an accurate and simple test for this purpose.