STUDY OF LYMPHOCYTE SUBSETS AND FUNCTION OF THE SUPPRESSIVE T LYMPHOCYTE IN PATIENTS WITH VIRAL MYOCARDITIS / 西安交通大学学报(医学版)

ABSTRACT

The frequency of peripheral lymphocyte subsets using monoclonal was studied in patients with viral myocarditis (MC). The percentage of T_8 positive cells was significantly lower in patients with MC of heart failure(MCHF) than that in patients with MC of arrhythmias and that in normal controls, whereas the T_4/T_8 ratio was significantly inereased in MCHF patients. At the same time, suppressive T cells (Ts) function in patients with MC was evaluated by shortlived assay. The Ts function was significantly reduced in MCHF patients, close correlation was found between the Ts function and the hemodynamic function in MCHF patients. Abnormal immunoreguiation may be of the important pathogenic factor in MCHF patients.