Preliminary study on the mechanism of cell adhesion activity of CEA / 中国免疫学杂志

ABSTRACT

Our previous experiment demonstrated that CEA is a cell adhesion molecule.The mechanism of cell adhesion activity of CEA was studied in this experiment using CEA positive cells line LoVo.Electron—micrographys study showed that LoVo cells adhered by cross contact of microvilli on the cell surface,and formation of gap junction and desomosomal junction were also observed.Cell adhesion activity of CEA was apperently influenced by emperature,NaN3,EDTA and cytochalasin B,showing that cell adhesion is an energy-consuming process depending on bivalent cation and movement of microfilament.A model of CEA on cell membrane was put forward.