The comparison of the effects of IL—2,IL—4 and IL—6 on the proliferative pesponses of T cells / 中国免疫学杂志

ABSTRACT

PHA,PMA or OKT3 McAb alone can not induce the proliferative responses of purified resting T cells,which enables us to comparise the effects of exogenous IL—2,IL—4 and IL—6 on the activation and proliferation of T cell.PHA can induce purifeid resting T cells responding to exgenous IL—2,IL—4 or Il—6 and anti—Tac(p55)McAb only blocked the proliferative response of PHA—stimulated T cells responding to IL—2.PMA can induce purified resting T cells responding to exogenous IL—2 or IL—4 but not Il—6.OKT3 McAb only induced the purified resting T cells responding to exogenous IL—2.Cyclsporin A,an immunosuppressant(CsA),inhibited the proliferative responses of PHA—stimulated T cells responding to exogenous IL—2,IL—4 or IL—6,but in the kinetic study of inhibitory affect of CsA,the results were completely different.Our data suggest that IL—2,IL—4 and IL—6 activate T cell by different pathway.