ALTERATION OF Na-K-ATPase IN ERYTHROCYTE AND ITS INFLUENCING FACTORS IN DIABETIC PATIENTS / 中华内分泌代谢杂志

ABSTRACT

We measured the Na-K-ATPase activity in erythrocyte membrane from 21 diabetic patients and 21 normal subjects with molybdenum blue colorimetry for inorganic phosphorus and Lowry's method for protein. Changes of this enzyme in erythrocyte membrane before and after treatment were also observed ia 13 diabetics. Our results demonstrated that the Na-K-ATPase activities in erythrocyte membrane from diabetic patients were lower than that from normal controls and no significant difference in Na-K-ATPase activity was observed before and after treatment in diabetics. Experiments in vitro revealed that lowered Na-K-ATPase activity in erythrocyte membrane from diabetics was not related to the serum insulin and glucose levels.