ACUTE AND CHRONIC EFFECT OF R-hGH ON PLASM AFREE AMINO ACIDS IN DWARFS WITH GROWTH HORMONE DEFICIENCY / 中华内分泌代谢杂志

ABSTRACT

The plasma free amino acids (FAA) of 10 dwarfs with growth hormone deficiency (GHD) were analysed at the beginning of and 3 months after R-hGH treatment in order to observe the acute and chronic effect of R-hGH on plasma FAA.At the beginning of and after 3-month treatment, the levels of more than half of the essential amino acids(EAA) and most of the non-essential amino acids (NEAA) decreased dramatically 4 hours after R-hGH injection, denoting that the amino acids were consumed in protein synthesis, gluconeogenesis, and ketogenesis. The magnitudes of relevant results after 3-month treatment were not as much as those at the beginning (although still statistically significant), suggesting a mild metabolic adaptation of body to long-term R-hGH treament.The significant low value of FAA and urea in fasting blood after 3-month treatment bespeaks a nitrogen retention. The striking decrease in glycine, proline, glutamic acid etc., proposes an increased need of amino acids for bone growth after long-term R-hGH treatment. To meet the demand of body development, an increase in protein nutrition during GH therapy is recommended.