EFFECTS OF Zn~(2+) ON THE NEUROMUSCULAR TRANSMISSION / 西安交通大学学报(医学版)

ABSTRACT

Experiments were carried out on the isolatedrat phrenic nerve diaphragm preparations and chickbiventer cervicis preparations. Zn~(2+) at cumulativeconcentration inhibited muscle contractile responseto indirect stimulation without affecting the con-ductivity of nerve. The inhibiting. action of Zn~(2+) onthe muscle contractile response to indirect stimula-tion was stronger than that on contractile responseto direct stimulation. Zn~(2+) did not affect the Achsensitivity of the chick biventer cervicis muscleThe effects of Zn~(2+) on neuromuscular transmis-sion were antagonized by Ca~(2+) and L-cystein.