In Vitro Antitumor Activities and phenotype Analysis of Tumor—infiltrating Lymphocytes(TIL)and Lymphokine—activating Killer(LAK)Cells From Patients With Osteosarcoma / 中国免疫学杂志
Chinese Journal of Immunology
;
(12)1985.
Article
in Chinese
| WPRIM
| ID: wpr-535428
ABSTRACT
TIL were isolated from the resected tumor mass,and lymphocytes were separated from pe-ripheral blood of 12 patients with osteosarcoma.In vitro antitumor activity and spesificity of rIL—2 activated TIL and LAK cells were determined by 4 hour ~(51)Cr releasing assay.Phenotypeanalysis of TIL were carried out in different intervals of incubation.The results revealed thatduring the incubation period from Day 15—Day 20,the difference between average cytolytic ac-tivities of TIL and LAK ceils with K562 and LiBr cells as target cells(ET ratio 251)were in-significant,while that from 7 of those patients with autotumor cells as target cells were signifi-cant.The phenotype analysis showed that the percentage of CD3~+ cells remained constant,whilethat of CD4~+ cells tends to increase,and that of CD8~+cells tends to decrease during the whole in-cubation period.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Immunology
Year:
1985
Type:
Article
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