CLINICAL OBSERVATION ON THE EFFECTIVENESS OF MICRONIZED GLIBENCLAMIDE / 中华内分泌代谢杂志

ABSTRACT

Seventy-six cases of NIDDM were collected and divided into 2 groups at random. 40 cases were treated with MIG (micro-glibenclamide) and 36 with OVG (old version glibenclamide) for 3 months. All patients were monthly followed-up for FPG.IRI (im-muno-reaction insulin) ,C-P,FMN(fructosamine),blood lipids and their pharmacokinetic behavior. The results showed that the total effectiveness of MIG for FPG in MIG group (51. 3% ,57. 5% ,79. 5%)monthly were better than that in OVG group(47. 2% ,55. 9% ,45. 7%). The results also suggested that MIG had a better results after a 3-month therapy,the diminished value of HbA, with MIG was more marked than with OVG (P