CHANGE IN NUMBER AND DISTRIBUTION OF PANCREATIC A- AND B-CELLS IN DIABETIC CHINESE HAMSTER / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12)1985.
Article
in Chinese
| WPRIM
| ID: wpr-535462
ABSTRACT
The change in pancreatic A- and B-cells in Chinese hamsters with spontaneous hereditary diabetes mellitus were investigated with specific immunohistochemical and image analyzing methods. A variety of pathological changes of the islets and change in number and distribution of the pancreatic A- and B-cells were found in diabetic Chinese hamsters. Microscopic examination revealed that the intensity of staining reaction of pancreatic B-cells varied greatly and the number of A-cells increased in this model. The results of image analysis showed that the range of the average optical density of B-cell staining was 54.4% wider than that in the control and the percentage of the glucagon positive immunoreactive area in the islet was significantly higher in diabetic Chinese hamsters(31.6?13.2%)than in the controls(21. 8?7.5%). These findings suggest that the islet cytology of this diabetic model changes significantly.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Endocrinology and Metabolism
Year:
1985
Type:
Article
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