DISTRIBUTION AND SIGNIFICANCE OF FACTOR X-LIKE ANTIGEN IN PANCREATIC ISLETS AND THEIR TUMOURS / 中华内分泌代谢杂志

ABSTRACT

The factor X-like antigen in normal pancreatic islets and in 52 cases of pancreatic endocrine tumours was investigated by immunohistochemistry. It was found that A cells and PP cells showed positive immunostaining for factor X-like antigen. Benign glucagonomas and PP-omas presented the highest concentrations of the immunoreactive material. Some benign insulinomas also presented factor X-like antigen. In malignent endocrine tumours of the pancreas immunohistochemical expression of factor X-like antigen was generally low or absent. The possible implications of the present findings for coagulative disorders associated with endocrine tumours were discussed.