Nerve function and nerve sorbitol content changes in diabetic rats and the effect of sodium fulvate / 中华内分泌代谢杂志

ABSTRACT

Objective To observe the changes of nerve function and nerve sorbitol in diabetic rats and to explore the effect of sodium fulvate (SF). Methods Diabetic rats were induced by intraperitoneal injection of streptozotocin. One group of diabetic rats were given SF for six months. Plasma glucose, HbA 1c and nerve sorbitol were measured, and pain threshold was detected by thermalpain apparatus and hotplate test. Results (1)There was no effect of SF on hyperglycemia in diabetic rats. (2)The withdrawal latency was significantly decreased and nerve sorbitol content was significantly increased in untreated diabetic rats. (3)Untreated diabetic rats showed pain reaction at non noxious temperature (40℃) and the times of hind paw withdrawal reflex per minute at 44℃ were increased in hotplate test 〔(3.42?0.59)/min〕 as compared with non diabetic control group 〔(0.88?0.36)/min〕 (P