Effects of vitamin D_3 and vitamin K_3 on experimental urolithiasis in rats / 中华泌尿外科杂志
Chinese Journal of Urology
;
(12)2000.
Article
in Chinese
| WPRIM
| ID: wpr-535725
ABSTRACT
Objective To investigate the relationship between urolithiasis and vitamin D 3 as well as vitamin K 3. Methods 36 adult male SD rats were randomized to control group、stone forming group、vitamin D 3 group、vitamin D 3+stone forming group、vitamin K 3 group and vitamin K+stone forming group.OPN and its mRNA of kidneys were detected,and the crystal components in urine were determined. Results Vitamin D 3 and vitamin K 3 could enhance the expression of OPN mRNA in rat kidneys of stone models.Vitamin D 3 could increase the concentration of calcium in urine significantly.Vitamin K 3 could inhibit the excretion of oxalate in urine and also inhibits the deposition of oxalate crystals in kidney. Conclusions The results indicated that vitamin D 3 may promote stone formation via various mechanisms,whereas vitamin K 3 could inhibit this process.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
Chinese Journal of Urology
Year:
2000
Type:
Article
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