The role of angiotensin Ⅱ and its receptor in the pathogenesis of diabetic cardiomyopathy / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12)1986.
Article
in Chinese
| WPRIM
| ID: wpr-535891
ABSTRACT
Objective To investigate the role of local angiotensin Ⅱ (ATⅡ) and its receptor (ATR) in the pathogenesis of diabetic cardiomyopathy. Methods Wistar rats were divided into two groups 3 month group included control and streptozotocin (STZ) induced diabetic rats and 6 month group included control, diabetic rats, and Losartan treated diabetic rats (3 mg?kg -1 ?d -1 orally from 3rd to 6th month after diabetes was induced). The cardiac function, ATⅡ and ATⅡ receptor were determined. Results The left ventricular diastolic dysfunction appeared in diabetes in 3rd month 〔-dp/dt max (687?86 vs 864?94)mm Hg/s, P
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
Language:
Chinese
Journal:
Chinese Journal of Endocrinology and Metabolism
Year:
1986
Type:
Article
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