Korean Medication Algorithm Project for Generalized Anxiety Disorder 2009 (II) : Medication Algorithm & Long-Term Medication Treatment Strategy / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 553-563, 2010.
Article
in Korean
| WPRIM
| ID: wpr-53594
ABSTRACT
OBJECTIVES:
This study was performed to investigate the consensus about medication algorithms, including long-term medication treatment strategies, in the treatment of generalized anxiety disorder (GAD).METHODS:
The executive committee of the Korean Medication Algorithm Project for GAD developed questionnaires about the psychopharmacologic treatment strategies for patients with GAD. Fifty-five (65%) of 84 experts of a reviewing committee answered the questionnaires. The consensus of expert opinion was classified into three categories, and the treatments of choice were selected by use of 95% confidence intervals and chi-square-tests.RESULTS:
The consensus on the first-line treatment strategy for GAD was as follows. Step 1 is the use of the one of a selective serotonin reuptake inhibitor (SSRI), a serotonin and noradrenaline reuptake inhibitor (SNRI) and buspirone for at least four to six weeks. Step 2 is to switch from a SSRI to a SNRI or buspirone or vice versa. Step 3 is to augment medication with an atypical antipsychotic or add a benzodiazepine or antihistamine. Step 4 is to switch to another combination, which includes a SSRI, a SNRI, mirtazapine or a tricyclic antidepressant Step 6 is to review the diagnosis, and 'benzodiazepines including clonazepam and alprazolam can be combined with another drug even from the initial period'. In terms of long-term medication treatment, the consensus first-line tr-eatment strategy involved the use of venlafaxine XR, escitalopram, fluoxetine, paroxetine CR, sertraline and buspirone.CONCLUSION:
This study provided information about the consensus among Korean experts regarding medication algorithms, including long-term medication treatment strategies, in the treatment of GAD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Anxiety
/
Anxiety Disorders
/
Psychopharmacology
/
Benzodiazepines
/
Alprazolam
/
Buspirone
/
Citalopram
/
Serotonin
/
Norepinephrine
/
Fluoxetine
Type of study:
Practice guideline
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Journal of Korean Neuropsychiatric Association
Year:
2010
Type:
Article
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