The use of sarcoglycan antibodies in diagnostic tests for sarcoglycanopathies / 中华神经科杂志
Chinese Journal of Neurology
;
(12)2000.
Article
in Chinese
| WPRIM
| ID: wpr-536014
ABSTRACT
Objective To study the characteristics of sarcoglycanopathies and their diagnostic methods.Methods On basis of dystrophin immunostaining,the muscle specimens of 25 LGMD with normal dystrophin were investigated using all four sarcoglycan (?,?,?,? sarcoglycan) antibodies by immunohistochemistry and Western blotting. Results 5 specimens showed a deficiency one case in ? SG,two in ? SG,one in three SG,and one in all four SG.Conclusion 5 patients were diagnosed as "sarcoglycanopathies". As it is difficult to distinguish the various types of LGMD based on clinical features,the immunohistochemistry and Western blotting of all four sarcoglycan antibodies may serve as an important diagnostic tool for sarcoglycanopathies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
Language:
Chinese
Journal:
Chinese Journal of Neurology
Year:
2000
Type:
Article
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