Adervances in the research of multidrug resistance-associated protein's biological characters and mechanism / 中国癌症杂志

ABSTRACT

Multidrug-resistance associated protein (MRP), a member of ATP-binding cassette superfamily transporters,confers multi-drug resistance by reducting intracellular drug concentrations and/or altering the pattern of intracellular drug distribution. Using mrp gene knockout models, researchers have found that a total block of mrp is compatible with life and its physiological functions seem to be an ATP-depending pump to co-transport free GSH and some presently unknown endogenous metabolites to protect the normal extracellular environment.