An experimental study of applicability of preventing prosthesis aseptic loosening by locally continuous administration of alendronate / 中华骨科杂志
Chinese Journal of Orthopaedics
;
(12)1996.
Article
in Chinese
| WPRIM
| ID: wpr-536112
ABSTRACT
Objective To determine the applicability of locally continuo u s application of alendronate for the prevention of prosthesis aseptic loosening. Methods Using the method of in vitro cell culture to detect the influence of a lendronate with different concentrations(1?10-11mol/L,1?10-9mol/L,1?10-7mo l/L,1?10-6mol/L,1?10-5mol/L) on the proliferation, secretion and osteogenesi s of human osteoblasts as well as the effect of the motility, respiration, phago cytosis and bactericidal ability. Results Higher concentration of alendronate(1 ?10-6mol/L,1?10-5mol/L) improved local antiinfection ability, but inhibited osteogenesis (1?10-5mol/L). Lower concentration(1?10-11mol/L,1?10-9mol/L,1 ?10-7mol/L) inhibited the bactericidal effect of neutrophils, but stimulated o steogenesis(1?10-11mol/L,1?10-9mol/L). Conclusion Locally continuously usin g alendronate around prosthesis to prevent and treat aseptic loosening must be h andled with discretion. Its concentration should not be below 1?10-6mol/L in the early period after arthroplasty operation, but the concentration should be 1?10-11mol/L or 1?10-9mol/L in the late period.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Orthopaedics
Year:
1996
Type:
Article
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