Serum levels of anti-gangliosides antibody in elderly patients with diabetic peripheral neuropathy / 中华老年医学杂志

ABSTRACT

Objective To characterize the relationship between diabetic peripheral neuropathy(DPN) and serum anti gangliosides antibody(GS). Methods Elderly patients were divided into three groups patients with type 2 diabetes mellitus(DM) showing no DPN,DM group, 25; DPN group, 32; healthy control group, 30. The nerve conduction velocity was measured using Nicolet Viking type IV electromyography(USA). The anti GSIgM Ab and anti GSIgG Ab were examined by solid enzyme immunoassay, and interleukin 1?(IL 1?), IL 2,tumor necrosis factor ?(TNF ?), HbA 1C and NO were also measured. Results The positive rate of anti GSIgM Ab and anti GSIgG Ab in DPN group being 65.6% and 34.4% respectively, was obviously higher than those in N group and DM group(P