The changes of Endothelin-1 and tumor necrosis factor-? in the congestive heart failure and the intervention role of vitamin E and vitamin C / 中国综合临床

ABSTRACT

Objective To study the level changes of tumor necrosis factor ? (TNF ?)and endothelin 1 (ET 1) and the intervention role of vitamin E and vitamin C in the patients with congestive heart failure (CHF).Methods 65 cases of heart failure were randomized into A group of 32 cases and B group of 33 cases.A group were given cardiotonic,diuretic and extending blood vessel drugs;B group were given 200 mg vitamin E once a day and 200 mg vitamin C three times a day,in the duration of two weeks,besides the medications administered to A group.Specific radioimmunoassay and double antibody sandwich ELISA were used to measure the concentrations of TNF ? and ET 1 of 65 cases with heart failure and 32 healthy subjects.Results The TNF ? and ET 1 levels of congestive heart failure patients were significantly higher than those in the control group (P