Clinical research of luterinizi releasing hormone anogist with zhibaidihuang pill treatment for girls idiopathic true precocious puberty / 中国基层医药

ABSTRACT

Objective To study the curative effect of luterinizi releasing hormone anogist(LRH-A) with Zhibaidihuang pill treatment for girls idiopathic true precocious puberty(ICPP).Methods 29 girls with ICPP,the breast in 3rd period were selected.9 of them were treated with LRH-A,12 of them were treated with LRH-A and Zhibaidihuang pill,8 of them as comparison group were no-treated.The growth speed,secondary sexual characteristics,bone age,LHRH inspire experiment,ultrasonic measurement of uterus volume and ovarian follicle size and forecast target of height were separately tested before and after treatment.Results Two groups after 4 period of treatment were comparedone group after only treated with LRH-A,the average growth speed was lower;The predict final target of height was not obviously increased;The secondary sexual characteristic reduced;The blood lever of E2,FSH and LH differ decreased;The bone age had no change.The other group after bio-treated with LRH-A and Zhibaidihuang pill,the average growth speed was slow down(P