Expression of P53 and its relationship with HBV infection in hepatocellular carcinomas and chronic liver diseases / 中国癌症杂志

ABSTRACT

Purpose:To study the expression of P53 and its relationship with hepatitis B virus(HBV) infection in hepatocellular carcinomas (HCC) and chronic liver diseases.Methods:HBsAg, HBcAg and P53 were detected by immunohistochemical staining and HBV DNA by in situ hybridization with total 98 cases of chronic hepatitis, liver cirrhosis, paratumor cirrhosis , HCC and normal liver tissue. Results:The positive rates of HBsAg, HBcAg and HBV DNA were 61.9%(13/21),42.9%(9/21) and 75.0%(12/16) in chronic hepatitis;64.0%(16/25),36.0%(9/25) and 83.3%(15/18) in liver cirrhosis; 72.7%(16/22),61.1%(11/18) and 85.7%(12/14) in the paratumor cirrhosis,as well as 45.2%(14/31),50.0%(14/28) and 64.3%(9/14) in HCC . The positive rate of P53 protein was 27.9%(12/43) in HCC. It was negative in the other groups.Conclusions:The expression of P53 occurs in the later stage of HCC .The infection of HBV is not related to the positive rate of P53 protein in HCC.