The Effect of Bevacizumab on Corneal Neovascularization in Rabbits
Korean Journal of Ophthalmology
;
: 230-236, 2010.
Article
in English
| WPRIM
| ID: wpr-53672
ABSTRACT
PURPOSE:
To determine the efficacy of topical application and subconjunctival injection of bevacizumab in the treatment of corneal neovascularization.METHODS:
Corneal neovascularization was induced with a silk suture of the corneal stroma in 12 rabbits (24 eyes). One week after suturing, four rabbits were treated with topical bevacizumab at 5 mg/mL (group A) and another four rabbits were treated with topical bevacizumab 10 mg/mL (group B) in the right eyes twice a day for two weeks. A subconjunctival injection of bevacizumab 1.25 mg/mL was done in the right eyes of four rabbits (group C). All of the left eyes (12 eyes) were used as controls. The area of corneal neovascularization was measured after one and two weeks, and the concentration of vascular endothelial growth factor (VEGF) in corneal tissue was measured after two weeks.RESULTS:
The neovascularized area was smaller in all treated groups than in the control group (p<0.001). Upon analysis of the neovascularized area, there was no significant difference between groups A and B. However, the mean neovascularized area of group B was significantly smaller than that of group C after two weeks of treatment (p=0.043). The histologic examination revealed fewer new corneal vessels in all treated groups than the control group. The concentration of VEGF was significantly lower in all treated groups compared to the control group (p<0.01), but no difference was shown between treated groups.CONCLUSIONS:
Topical and subconjunctival bevacizumab application may be useful in the treatment of corneal neovascularization and further study is necessary.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ophthalmic Solutions
/
Drug Administration Schedule
/
Follow-Up Studies
/
Treatment Outcome
/
Corneal Neovascularization
/
Cornea
/
Angiogenesis Inhibitors
/
Vascular Endothelial Growth Factor A
/
Disease Models, Animal
/
Dose-Response Relationship, Drug
Type of study:
Observational study
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
Korean Journal of Ophthalmology
Year:
2010
Type:
Article
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