C-fos Protein Expression of the Rats on the Brain after 12 Hours Sleep Deprivation of Day and Night / 中国临床心理学杂志

ABSTRACT

Objective: To investigate the brain mechanisms of sleep deprivation. Methods: Sprague-Dawley rats were sleep deprived by housing them on the small platforms over water. Controls were housed in the normal cage(CC) or on the large platforms over water(TC). The effects of SD on the expression of c-fos protein by immunocytochemistry were investigated. The duration of SD was about 12 hours. They were divided into two groups early SD group (from 700 am) and the late SD group (from 1900 pm). Results: SD resulted in different expression of c-fos protein at different fields of the brain. The main fields of brain stem were all connected with paradoxical sleep. Compared with the late SD, the early SD group showed higher fos protein expression on suprachiasmatic.Conclusion: The disruption of regular circadian rhythm may affect c-fos protein expression.