EFFECTS OF VERAPAMIL ON MYOCARDIAL PROTECTION DURING VALVE REPLACEMENT / 重庆医科大学学报

ABSTRACT

Effects of verapamil-potassium cardioplegic solution (CPS) OB myocardial protection were studied durig the ischemic period of aortic cross-ciatnping in patients undergoing valve replacement. 165 patients were divided into two groups.Croupl (n = 84) with cold potassium CPS, in which, Img/L of verapamil was added.Group 2 (n = 81) as control, with cold potassium CPS alone. As compared to the control group the results showed that (1) hearts were rapidly arrested in diastolic phase, electrocardiac activity was depre ssed more completeli; ( 2 ) before cardiac arret or following reperfusion the incidence of ventricular fibrillation were obviously less than control group,recovery of cardiac function after bypass was better ,and incidence of serious low-output syndromewas lower; (3) electron microscopic examination demonstrated myocardial ultrastructural changes, particularly mitochondrial damages were less and milder. It is concluded that verapamil intensifies the myocardial protective effect of cold CPS