The regulatory effects of PTK on neutrophils in response to transmembrane TNF-? and secreted TNF-? / 中国免疫学杂志
Chinese Journal of Immunology
;
(12)2000.
Article
in Chinese
| WPRIM
| ID: wpr-537183
ABSTRACT
Objective:
To study the effects of PTK on the respiratory burst and release of NO by neutrophils in response to transmembrane TNF-?( TM-TNF-?) and secreted TNF-? ( S-TNF-?).Methods:
The effects of PTK inhibitor on the functions of neutrophils caused by both forms of TNF-? was detected with the chemiluminescence and the nitrate reductase assay.The tyrosine phosphorylation of neutrophils induced by the two forms of TNF-? was compared by Western blotting analysis.Results:
The PTK inhibitor genistein (50 ?mol/L) was found not only to depress the respiratory burst of neutrophils induced by S-TNF-?( P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Immunology
Year:
2000
Type:
Article
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