Expressions of p53, p21/WAF1 and pRb in the prognosis of T_1G_3 bladder cancer / 中华泌尿外科杂志

ABSTRACT

Objective To evaluate the prognostic significance of p53, p21/WAF1 and pRb in T 1G 3 transitional cell carcinoma (TCC) of the urinary bladder. Methods Paraffin embedded sections from 47 patients with T 1G 3 TCC of the bladder were studied by immunohistochemistry, using monoclonal antibodies of p53, p21/WAF1 and pRb. The immunostaining results were analyzed in relation to the tumor progression, and compared with the clinical parameters on prognostic significance. Results Of the 39 patients treated by TURBT or partial cystectomy, the total progression rate of the tumor has been 59%.Of the 8 patients treated by cystectomy,one had pulmonary metastasis 2 years after the operation.The abnormal expression rates of p53, p21/WAF1 and pRb were 66.7%, 51.4% and 71.8% respectively. Multivariate analysis indicated that only the combined abnormal expressions of p53, p21/WAF1 and pRb provided prognostic information in T 1G 3 TCC of the bladder. Conclusions Immunohistochemical evaluation of p53, p21/WAF1 and pRb nuclear expressions would help the prognostic evaluation cases of T 1G 3 TCC of the bladder.