Dystrophin expression in mdx mouse restored by bone marrow transplantation / 中华神经科杂志
Chinese Journal of Neurology
;
(12)1999.
Article
in Chinese
| WPRIM
| ID: wpr-537483
ABSTRACT
Objective Duchenne muscular dystrophy (DMD) is a lethal inherited disorder; the main pathogenesis is deficiency of dystrophin Our study is to observe dystrophin expression in myofibers of mdx mice (an animal model of DMD) transplanted with different bone marrow cells Methods Bone marrow cells, suspension cells and stromal cells were cultured in vitro from C57BL male mice, and these cells were transplanted respectively by tail vein of irradiated mdx mice Dystrophin expression of female mdx mice was detected dynamically By using PCR technique, Y chromosome specific sex determining regions were detected dynamically with the blood of transplanted female mdx mice Results Few dystrophin expression in myofibers (
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Neurology
Year:
1999
Type:
Article
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