An experimental study of PDGF-A and PDGF-?R expression in osteoporotic fracture healing / 中华骨科杂志
Chinese Journal of Orthopaedics
;
(12)1998.
Article
in Chinese
| WPRIM
| ID: wpr-537503
ABSTRACT
Objective To observe the expression of platelet-derived growth factor A(PDGF-A) and PDGF-?R in callus during osteoporotic fracture healing and to explore further into the mechanism or effect of PDGF-A and PDGF-?R on osteoporotic fracture healing. Methods The expression and change of PDGF-A and PDGF-?R in different period of osteoporotic fracture healing(5, 7, 14, 28, 42 days) were investigated by means of immunohistochemistry(ABC method). Results There were different cells origin (chondrocyte, osteoblast, osteocyte, vascular endothelial cell, et al) and degree of expression of PDGF-A and PDGF-?R in callus during different period of osteoporotic fracture healing. Conclusion PDGF-A moderates and participates in osteoporotic fracture healing. The decrease of osteoporotic fracture repair capacity may correlate with abnormality of PDGF-A secretion.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Orthopaedics
Year:
1998
Type:
Article
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