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Aging attenuates the neuroprotective effect by preconditioning with 3-nitropropionic acid / 中华老年医学杂志
Chinese Journal of Geriatrics ; (12)2001.
Article in Chinese | WPRIM | ID: wpr-537553
ABSTRACT
Objective To investigate the effect of aging on neuroprotection by preconditioning with 3-nitropropionic acid (3-NPA) and the relationship between aging and adenosine receptor. Methods Population spike amplitude (PSA) in region CA 1 in hippocampal slices was measured during 15 min hypoxia and 45 min posthypoxic recovery from adult and aged mice, which were pretreated in vivo with a single intraperitoneal injection of 3-NPA (20 mg/kg). Posthypoxic PSA recovery was also observed after perfusion with selective agonist or antagonist of adenosine A 1 and A2a receptors. Results Posthypoxic recovery of PSA increased from 26.1?12.2% in control slices to 92.9?15.3% in pretreated slices from adult (P

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Geriatrics Year: 2001 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Geriatrics Year: 2001 Type: Article