Genetic Damages of Nurses Exposed to Antineoplastic Agents / 环境与健康杂志

ABSTRACT

Objective To observe the genetic damages relate d to occupational exposure to antineoplastic agents without special protective measures in exposed subjects.Methods The damages of DNA and chromosomes of peripheral blood lym-phocytes were determined by comet assay and cytokinesis-block micronucleus test in exposure group consisting of24nurses oc-cupationally exposed to antineoplastic agents without special protective measures and control group consisting of24female doc-tors without exposure to antineoplastic agents in oncology department in a certain hospital.Results The exposure group showed significantly higher micronucleus rate(13.25‰?5.17‰)compared with that of control group(3.79‰?2.19‰),P