Inhibitary effects of hydroxycampothecin, pingyangmycin, cis-platinum or their combination on the human tongue carcinoma cells / 实用口腔医学杂志
Journal of Practical Stomatology
;
(6)2001.
Article
in Chinese
| WPRIM
| ID: wpr-537619
ABSTRACT
objective:
To study the effects of hydroxycampothecin(HCPT), pingyangmycin(PYM), cis platinum (DDP) or their combination on the proliferation of human tongue carcinoma Tca8113 cells.Methods:
MTT assay, cell counting,clonogenic assay and HE staining were used to study the effects of HCPT, PYM, DDP or their combination on the proliferation of human tongue carcinoma Tca8113 cells.Results:
①Synergistic inhibiton was observed when HCPT at the concentration (ng/ml) of 10~100 combined with PYM at 32~320 or DDP at 32~320, antagonistic effect was observed when PYM at 32~320 combined with DDP at 32~320; ②After treatment with PYM, HCPT or PYM plus HCPT at IC 30 the clonogenecity (%) of the cells was 15.2, 11.6 and 4.1 respectively, while that of untreated cells 31.7.Conclusion:
The combination of HCPT with PYM may be synergistic in the inhibition of tongue carcinoma cell proliferation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Practical Stomatology
Year:
2001
Type:
Article
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