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The dose-effect relationship between active DNA and SLE-like syndrome and its characteristic / 中国免疫学杂志
Chinese Journal of Immunology ; (12)1985.
Article in Chinese | WPRIM | ID: wpr-537692
ABSTRACT

Objective:

To study the relationship between the dose of active DNA and the induction of SLE-like syndrome.

Methods:

DNA from extracted ConA-activated spleen lymphocytes and immunized syngenic mice with different quantities of active DNA, the anti-dsDNA antibodies and anti-histone antibodies as well as the antibody subclass were detected by ELISA.The patterns of antinuclear antibodies and immune complexes in glomeruli were observed by immunofluorescent-stain.

Results:

10 pig active DNA could induce all the animal to produce anti-dsDNA and anti-histone antibodies,and the induced autoann'bodies were mainly IgGl type.Only 25%animals produced autoantibodies immunized by 5 fjig active DNA.

Conclusion:

The minimum dose of active DNA to induce SLE-like syndrome was 10

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Immunology Year: 1985 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Immunology Year: 1985 Type: Article