The expression of protein kinase C subforms in renal cell carcinoma and its clinical significance / 中华泌尿外科杂志

ABSTRACT

ObjectiveTo study the expression of three protein kinase C subforms in renal cell carcinoma.MethodsThe expression of cPKC?,cPKC? Ⅱ and aPKC? in renal cell carcinoma were detected by immunohistochemical method(S-P method) and by in situ hybridization.ResultsPositive rate of cPKC? ?cPKC? Ⅱ and aPKC? was 68.4%,34.2% and 44.7% respectively in renal cell carcinoma.Positive rate of cPKC? in stage T 2～T 4 tumors was 80.9%(17/21) and 52.9%(9/17) in T 1(P 0.05).The positive expression of cPKC? in deadly cases was significantly higher than in survivers (P