Update on NSAIDs Related Peptic Ulcers / 대한내과학회지
Korean Journal of Medicine
;
: 664-672, 2014.
Article
in Korean
| WPRIM
| ID: wpr-53787
ABSTRACT
Nonsteroidal anti-inflammatory drugs (NSAIDs) have analgesic, antipyretic, and anti-inflammatory properties and are widely used for treating musculoskeletal and cardiovascular diseases. Notwithstanding these therapeutic efficacies, gastrointestinal toxicity is the major health problem associated with NSAID use. NSAID-related peptic ulcers are a well-known complication due to direct mucosal injury and cyclooxygenase inhibition. Risk factors for NSAID-related peptic ulcers include a prior history of peptic ulcer; age > 65 years; high-dose NSAID therapy; and concurrent use of aspirin (including low dose), corticosteroids, or anticoagulants. In addition, Helicobacter pylori infection is an independent risk factor; therefore, eradication therapy is recommended in high-risk patients using NSAIDs. Currently, misoprostol, H2-receptor antagonists, proton pump inhibitors, and COX-2 selective inhibitors are used to prevent and treat NSAID-related peptic ulcers. Further, strategic approaches are required through appropriate NSAID use and risk factor stratification to prevent NSAID-related peptic ulcers and associated complications.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peptic Ulcer
/
Cardiovascular Diseases
/
Anti-Inflammatory Agents, Non-Steroidal
/
Aspirin
/
Risk Factors
/
Helicobacter pylori
/
Misoprostol
/
Prostaglandin-Endoperoxide Synthases
/
Adrenal Cortex Hormones
/
Proton Pump Inhibitors
Type of study:
Etiology study
/
Risk factors
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS