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Helicobacter pylori-related Peptic Ulcer Disease / 대한내과학회지
Korean Journal of Medicine ; : 655-663, 2014.
Article in Korean | WPRIM | ID: wpr-53788
ABSTRACT
Although the worldwide prevalence of Helicobacter pylori (H. pylori) infection has decreased, peptic ulcer disease (PUD) remains prevalent due to increased usage of non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin. In recent years, the prevalence of H. pylori infection in PUD cases and the distribution of PUD have changed in Korea. The incidence of idiopathic H. pylori-negative ulcers has increased, and research is needed to determine the cause of these idiopathic ulcers. The eradication of H. pylori infection decreases PUD recurrence, and plays a crucial role in the treatment of PUD. The H. pylori test-and-treat strategy is beneficial for patients starting NSAIDs and long-term aspirin users with a history of bleeding ulcers. Although the H. pylori eradication rate is declining steadily due to antibiotic resistance, especially to clarithromycin, current guidelines still recommend standard triple therapy, including a proton pump inhibitor, amoxicillin, and clarithromycin, as a first-line therapy. Recently, various treatment regimens, including sequential or concomitant therapies, have been developed in an attempt to overcome the low eradication rate observed with standard triple therapy. The aim of this article is to review recent trends in H. pylori-related PUD, focusing on epidemiology and treatment strategies.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Peptic Ulcer / Recurrence / Ulcer / Drug Resistance, Microbial / Anti-Inflammatory Agents, Non-Steroidal / Aspirin / Epidemiology / Incidence / Prevalence / Helicobacter pylori Type of study: Practice guideline / Incidence study / Prevalence study / Prognostic study Limits: Humans Country/Region as subject: Asia Language: Korean Journal: Korean Journal of Medicine Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Peptic Ulcer / Recurrence / Ulcer / Drug Resistance, Microbial / Anti-Inflammatory Agents, Non-Steroidal / Aspirin / Epidemiology / Incidence / Prevalence / Helicobacter pylori Type of study: Practice guideline / Incidence study / Prevalence study / Prognostic study Limits: Humans Country/Region as subject: Asia Language: Korean Journal: Korean Journal of Medicine Year: 2014 Type: Article