Histopathological features of bone metastases from prostatic carcinoma after castration / 中华泌尿外科杂志

ABSTRACT

Objective To understand the histologic changes of prostatic carcinoma's bone metastases and other associated observations,and to provide histopathological basis for clinical therapy. Methods Seven patients with prostatic carcinoma bone metastases,whose needle biopsy of prostate and bone metastases was positive,were treated by hormone castrative therapy.The changes of prostatic primary carcinoma,bone metastases and correlated examinations were observed,and the results were compared with those before treatment. Results The prostatic tumors of 7 patients disappeared in 2 months after treatment.The prostate specific antigen (PSA) level of 5 patients returned to normal within 2 months.Two patients had orthopedics surgery because of spinal epidural compression symptom,and their pathologic examination of bone metastases showed that the transparent cells disappeared,the number of tumor bone trabecula reduced and immunohistochemical stains of PSA was negative.Another 2 patients had bone excision because of the development of bone metastases.Transparent acinose cells,mixed with many tumor-like bone tissues,could be found in the focus,with immunohistochemical stains being positive compatible with the changes of focal bone,PSA and imageology examination showed corresponding results. Conclusions Castration therapy can make carcinoma cells of the prostate and bone metastases,partially or completely,disappear.However,part of bone metastases changes may not be consistent with those of primary carcinoma.PSA and imageology examination may show the correlated changes of bone metastases,and provide exact basis for the clinical treatment.