Effects of Organic Extracts of Drinking Water in a City on the Ovary of Mice / 环境与健康杂志

ABSTRACT

Objective To determine the effects of organic extracts of drinking water on female mice reproductive system.Methods The Kunming female mice were randomly divided into4groups,one as reagent control group,the other three as treated groups,15female mice per group.The treated groups were treated with the organics extracted from the chlorinated drinking water by the solid phase extraction at the doses of12.5,25and50L/kg respectively,once a day,continuously for5d.The pathological changes of ovary were observed by optical microscopy.Results At the10th day after treatment,the number of intermediate follicles andⅡatretic follicles in ovary in the treated group significantly increased,especially the number ofⅡa-tretic follicles in25L/kg group,which was10times as high as that in the control group.At the30th day after treatment,the number of normal follicles revealed no significant changes,the number ofⅡatretic follicles in the25and50L/kg group was still significantly higher than that in the control group,the number of corpora lutea in ovary significantly decreased with the in-creases of doses.The estrous cycle delayed at the level of50L/kg.Conclusion The organic extracts from drinking water had adverse effects on the female reproductive system by affecting the development and maturity of the follicles.