Study on the Genotoxicity of Bromate / 环境与健康杂志

ABSTRACT

Objective To study the genotoxicity of bromate,a chief by-product of ozonated drinking water.Methods Genotoxicity at gene,DNA and chromosome levels induced by bromate DBP was determined using Ames test,unscheduled DNA synthesis(UDS)assay and micronucleus test(MNT)of mice bone marrow polychromatic erythrocytes respectively.Results In Ames test,bromate showed no mutagenic effect on salmonella typhimurium TA98and TA100strains with or without S9(rat liv-er metabolic activation system)compared with the negative control group,but the results of UDS assay showed that bromate could induce unscheduled DNA synthesis in rat primary hepatocytes and the results of MNT indicated that bromate increased the micronucleus rate of bone marrow polychromatic erythrocytes of mice.Conclusion It was suggested that bromate DBP might have genotoxicity at DNA and chromosome levels.