Effects of almitrine-raubasine on learning-memory ability in chronic episodic hypoxia rat and possible biochemical mechanism involved / 中华神经科杂志
Chinese Journal of Neurology
;
(12)2000.
Article
in Chinese
| WPRIM
| ID: wpr-538585
ABSTRACT
Objective To investigate the effects of almitrine-raubasine on learning-memory ability and brain choline acetyltransferase (ChAT) activity in chronic episodic hypoxia (EHYP) rat. Methods After establishing the rat model of EHYP, almitrine-raubasine (0.03 tablets/250 g body weight , Bid) was given to the EHYP rats. The learning-memory ability was evaluated by using passive avoidance test and the ChAT activity in three different brain regions (including cerebral cortex, hippocampus and striatum) was determined using radiochemical method. Results As compared with the controlled rats, the performance on passive avoidance test of EHYP rats was impaired significantly (P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Neurology
Year:
2000
Type:
Article
Similar
MEDLINE
...
LILACS
LIS