Effect of verapamil on ischemic random skin flaps in rats / 中华医学美学美容杂志
Chinese Journal of Medical Aesthetics and Cosmetology
;
(6)2001.
Article
in Chinese
| WPRIM
| ID: wpr-538779
ABSTRACT
ObjectiveTo investigate the effect of verapamil on the i schemic random skin flaps. MethodsThe dorsal random skin flap s of Wistar rats were raised (length/width=6/1). Verapamil was injected under th e flaps at the dose of 25mg/kg after the operations. Seven days later, the necro sis rate, the content of molondialehyde (MDA) in middle segment and the microsco pic observation were studied. ResultsThe necrosis rates were 1 5.9 % in verapamil group and 21.8 % in control group. The content of MDA in midd le segment of verapamil group was 164.8 nmol/L, and that in control group was 19 5.8 nmol/L. The difference was very significant. Under the microscope, the tissu e inflammatory reactions in the experiment group were not so severe as that in t he control group. ConclusionVerapamil improves the survival of the ischemic random skin flaps and it is applicable to give verapamil by subcut aneous injection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
Chinese Journal of Medical Aesthetics and Cosmetology
Year:
2001
Type:
Article
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