Screening of the interaction protein with Wnt signaling molecular-TCF4 from renal carcinoma cDNA library by yeast two hybrid / 中华泌尿外科杂志
Chinese Journal of Urology
;
(12)2000.
Article
in Chinese
| WPRIM
| ID: wpr-538800
ABSTRACT
ObjectiveTo investigate the interaction pr otein with Wnt signaling molecular-TCF4 in renal carcinogenesis.Me thodsThe N terminal and DNA binding domain of human T cell factor 4 (TCF4ND, 1~495 aa) was used as a bait to screen the renal carcinoma cDNA libra r y by yeast two hybrid.Results51 positive colonies were fished out such as ?-catenin,TCF4,activating transcription factor 5(ATF5),and 2 unknown genes.ConclusionsIt is indicated that exten sive signaling cross-talks between Wnt and other signaling pathways might play an significant role in renal carcinogenesis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
/
Screening study
Language:
Chinese
Journal:
Chinese Journal of Urology
Year:
2000
Type:
Article
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