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Research advances in drug transporters and multidrug resistance / 中国癌症杂志
China Oncology ; (12)2000.
Article in Chinese | WPRIM | ID: wpr-538830
ABSTRACT
Multidrug resistance (MDR) is the most common cause in the failure of cancer chemotherapy. Drug transporters play an important role in multidrug resistance in cancer. Activation of drug pumps which belong to ATP-binding cassette (ABC) transporters leads to the efflux of drug via cell membrane.Three subgroups of ABC transporters are involved in the transport of cytotoxic drugs.These transporters include ABCB subgroup,ABCC subgroup and ABCG subgroup. In this review,the author discussed the recent research advances in the ABC transporters associated with MDR.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Oncology Year: 2000 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Oncology Year: 2000 Type: Article