The relieving effect of cyclooxygenase inhibitors and prostaglandin receptor blocker on hyperalgesia of diabetic rats / 西安交通大学学报(医学版)
Journal of Xi'an Jiaotong University(Medical Sciences)
;
(6)2003.
Article
in Chinese
| WPRIM
| ID: wpr-538933
ABSTRACT
Objective To observe the effects of cyclooxygenase (COX) inhibitors and prostaglandin (PG) receptor blocker on hyperalgesia of diabetic rats. Methods Nociceptive paw-withdrawal threshold (NPWT) and thermal latency (TL) of diabetic hyperalgesic rats were tested after subcutaneous injections of COX inhibitors indomethacin and meloxicam, and EP 1 PG receptor blocker SC-19220 into the dorsum of the hindpaw of the rats. Results Indomethacin, a classic inhibitor of COX, produced a significant and long-lasting relief of mechanical hyperalgesia in diabetic hyperalgesic rats. Meloxicam, a selective cyclooxygenase 2 (COX-2) inhibitor, alleviated mechanical and thermal hyperalgesia, but with a shorter duration. SC-19220, a selective EP 1 PG receptor blocker, produced significant relief of mechanical and thermal hyperalgesia. Conclusion COX inhibitors and EP 1 PG receptor blocker relieve hyperalgesia of diabetic rats, which suggests that PGs play an important role in inducing and maintaining hyperalgesia in diabatic rats.
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Xi'an Jiaotong University(Medical Sciences)
Year:
2003
Type:
Article
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