Microvessel density and expression of vascular endothelial growth factor in squa mous cell carcinomas of gingiva / 实用口腔医学杂志
Journal of Practical Stomatology
; (6)2001.
Article
in Zh
| WPRIM
| ID: wpr-539035
Responsible library:
WPRO
ABSTRACT
Objective:To determine the effects of angiogenesis in c ervical lymph node metastasis and progression of squamous cell carcinomas of gin giva (GSCC), and the distribution and expression of vascular endothelial growth factor (VEGF) in GSCC.Methods: Paraffin sections of surg ically obtained GSCC samples from 42 patients were stained with CD34 monoclon al antibody by immunohistochemical S P method to demonstrate blood vessels. Exp ression of VEGF was tested with the S P method, and the microvessel density (M VD) was determined according to the percent of the neoplastic cells showing VEG F immunoreactivity and the degree of staining.Results: The MVD in GSCC was significantly higher than that in normal gingival tissue( P 0.05). MVD in VEGF positive samples of GSCC was sig nificantly higher than that in VEGF negative ones ( P
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Index:
WPRIM
Language:
Zh
Journal:
Journal of Practical Stomatology
Year:
2001
Type:
Article