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A multivariate analysis of cadaver renal transplantation for long-term survival / 中华器官移植杂志
Chinese Journal of Organ Transplantation ; (12)1996.
Article in Chinese | WPRIM | ID: wpr-539561
ABSTRACT
Objective To review the kidney transplantation performed in our center and analyze the risk factors affecting long-term allografts survival. Methods Thirty two relative variables were analyzed by SAS statistical software. Using Log-Rank method, the influence of these variables on short and long-term grafts survival was investigated. A Kaplan-Meier analysis was used to estimate the 1-, 3-, 5-, 10-year graft survival rate and its half-life. Proportional hazards regression analysis (Cox model) was used to assess and rank the relative risk of potential variables.Results The 1-year, 3-year, 5-year, 10-year grafts survival rate was 82.5 %, 75.2 %, 65.5 % and 48.4 % respectively. When excluding the patients died with functioning grafts, the 1-year, 3-year, 5-year, 10-year grafts survival rate was increased to 91.0 %, 82.0 %, 75.9 %, 68.5 %, respectively. The mean half-life was 8.78? 0.14 and 14.09? 0.20 years, respectively. By Log-Rank analysis, factors affecting short- and long-term grafts survival were identified as renal function and duration of which become normal, cold-ischemia time, acute rejection, delayed grafts function, immunosuppressive regimen, complication, infection, the method of anti-rejection therapy. A Cox model multivariate analysis showed that there were 18 factors affecting graft survival.Conclusion New immunosuppressive agent not only has significantly increased short-term graft survival, but also prolonged the long-term survival. Making assurance to get high quality donor organ and minimizing the death with graft function may be the most feasible way to prolong a graft survival at present.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Etiology study / Prognostic study / Risk factors Language: Chinese Journal: Chinese Journal of Organ Transplantation Year: 1996 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Etiology study / Prognostic study / Risk factors Language: Chinese Journal: Chinese Journal of Organ Transplantation Year: 1996 Type: Article