Plasma Levels of N-terminal pro-brain Natriuretic Peptide (NT-proBNP) and Left Ventricular Function in Patients with Chronic Renal Failure / 대한신장학회잡지
Korean Journal of Nephrology
;
: 413-421, 2006.
Article
in Korean
| WPRIM
| ID: wpr-53973
ABSTRACT
BACKGROUND:
Circulating levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) have been used to identify and monitor myocardial dysfunction in patients with various cardiac diseases. However, its clinical significance in patients with chronic renal failure (CRF) is uncertain because NT-proBNP clearance may be affected by renal function.METHODS:
We studied 331 patients with CRF (eGFR 0.01) was strong independent correlate of NT-proBNP, eGFR (beta=-0.358, p0.01) and diastolic dysfunction 2 or higher (beta=0.171, p< 0.05) were also independent correlates of NT-proBNP. Receiver-operating characteristic (ROC) analyses demonstrated NT-proBNP to be 75% sensitive and 76% specific for the detection of left ventricular systolic dysfunction, as indicated by area under the ROC curve of 0.78 (p<0.05), with NT-proBNP cutoff concentration of 25,000 pg/mL.CONCLUSION:
Circulating NT-proBNP levels increased with declining renal function. However, its level were significantly correlated with LVH, systolic and diastolic dysfunction in patients with CRF. The measurement of NT-proBNP levels might be useful to predict left ventricular dysfunction in patients with CRF.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Echocardiography
/
ROC Curve
/
Ventricular Function, Left
/
Hypertrophy, Left Ventricular
/
Ventricular Dysfunction, Left
/
Heart Diseases
/
Kidney Failure, Chronic
Type of study:
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Nephrology
Year:
2006
Type:
Article
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